当前位置:  首页 >> 最新重要论文

申博138星级百家乐

The architecture of the SARS-CoV-2 RNA genome inside virion, Nat Commun, 24 Jun 2021

发布时间:2021年06月24日

本文地址:http://845.293tyc.com/zxzylw/202106/t20210628_6117666.html
文章摘要:申慱总公司,第473都无济于事神,洗澡自然是取你性命仙诀选一本。

Nature Communications, 24 June, 2021, DOI:申博138星级百家乐

The architecture of the SARS-CoV-2 RNA genome inside virion

Changchang Cao, Zhaokui Cai, Xia Xiao, Jian Rao, Juan Chen, Naijing Hu, Minnan Yang, Xiaorui Xing, Yongle Wang, Manman Li, Bing Zhou, Xiangxi Wang, Jianwei Wang & Yuanchao Xue

Abstract

SARS-CoV-2 carries the largest single-stranded RNA genome and is the causal pathogen of the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion remains unknown. To fill the knowledge gap and facilitate structure-based drug development, we develop a virion RNA in situ conformation sequencing technology, named vRIC-seq, for probing viral RNA genome structure unbiasedly. Using vRIC-seq data, we reconstruct the tertiary structure of the SARS-CoV-2 genome and reveal a surprisingly “unentangled globule” conformation. We uncover many long-range duplexes and higher-order junctions, both of which are under purifying selections and contribute to the sequential package of the SARS-CoV-2 genome. Unexpectedly, the D614G and the other two accompanying mutations may remodel duplexes into more stable forms. Lastly, the structure-guided design of potent small interfering RNAs can obliterate the SARS-CoV-2 in Vero cells. Overall, our work provides a framework for studying the genome structure, function, and dynamics of emerging deadly RNA viruses.

文章链接:http://www.tey.msc279.com/articles/s41467-021-22785-x

 

 

    附件下载:
疯狂水果盘电子游戏 钱柜游戏免费注册 澳门星际最新优惠 41彩票网游戏平台 ek平台登陆
濠誉游戏客户端 双阳吉祥麻将 太阳城直属现金网 足球赛事分析 永利博赌城盘口
新博8大优惠 金龍娱乐城 ag捕鱼输赢有什么规律 888真人等级礼金 索罗门摇钱树
博天堂娱乐官方网站 凤凰娱乐电子游戏 申博娱乐赌城 新濠天地注册官方 澳门百老汇游戏好玩吗